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 utopian pharmacology mental health in the third millennium mdma and beyond mdma/ecstasy a brief history of mdma the mdma experience mdma : neurotoxicity mdma : neuroprotection ecstasy for life? the molecular machinery of magic post-darwinian medicine beyond mdma : mental superhealth mdma/ecstasy can safe, sustainable analogues of mdma be developed? there is an urgent need for non-neurotoxic empathogens and entactogens suitable for lifelong use. alas no single "magic bullet" yet exists that replicates the subjective effects of mdma on a long-term basis. hence most of us are doomed to display the quasi-psychopathic indifference to each other characteristic of the mdma-naïve state. a brief history of mdma mdma [3,4-methylenedioxy-methamphetamine: ' ecstasy '] was first 1 synthesized in 1912 by the german pharmaceutical company merck . mdma was patented in darmstadt, germany on may 16th 1914, issue number 274,350; and promptly forgotten. merck's researchers had no idea of the significance of what they had done. merck were searching for a good vasoconstrictor, a styptic to reduce bleeding. in 1912 two of their chemists, g. mannish and w. jacobsohn, created mdma as a by-product while attempting to synthesise hydrastinin. mdma is listed on merck's patent-application merely as a chemical intermediate "for products of potential pharmaceutical value". mdma surfaced again briefly as one of a number of agents used in clandestine us military research during the 1950s. the cia 's project mk-ultra was investigating new techniques of brainwashing, espionage and mind-control. mdma, code-named ea-1475, was tested at the us army's edgewood arsenal in maryland. however, unlike lsd or the ill-named "truth drug" scopolamine , mdma was used only on non-human animals: mice, rats, pigs, monkeys and dogs. thankfully, mdma's military potential was not realised. for although mdma is no infallible truth-serum, its effects on the human user might indeed be abused for sinister purposes by skilled interrogators. the heightened emotional responsiveness, lowering of defensive barriers, openness and sense of closeness to others induced by mdma can promote an honesty of self-disclosure that might be manipulated for malign ends. fortunately, this hasn't yet happened on an organised scale. mdma's parent and longer-acting metabolite, 3,4-methylenedioxyamphetamine [ mda ] was first synthesized in 1910 by the same two unsung merck researchers who went on to create mdma. mdma differs structurally from mda only in its additional methyl group attached to the nitrogen atom. mda's own empathy-enhancing effect at low doses was explored by chilean anthropologist-psychiatrist dr claudio naranjo in his private practice. dr naranjo discusses mda-assisted therapy in his classic the healing journey (1973). mda was patented by drug company smithkline french for use as a tranquilliser (1960) and appetite-inhibitor (1961). smithkline were interested in mda's potential as an antidepressant and a slimming-drug. in 1958 human trials were conducted; unfortunately the compound was to prove too psychedelic for licensed clinical use. but mda was popular as "the love drug" in the counterculture of the 1960s. the identity of the first human being to take mdma/ecstasy isn't known. the drug gained prominence only in the late 1970s. tipped off by merrie kleinman, a graduate student in the medicinal chemistry group he advised at san francisco state university, the legendary californian psychedelic chemist alexander ("sasha") shulgin (1925 - 2014) synthesized and taste-tested mdma at incrementally ascending doses. ironically, dr shulgin had himself synthesized mdma in 1965, but hadn't tried it, an error of omission he later did much to repair . the effects of a 120mg dose of mdma are recorded in dr shulgin's lab-notes (sept 1976): "i feel absolutely clean inside, and there is nothing but pure euphoria. i have never felt so great or believed this to be possible. the cleanliness, clarity, and marvelous feeling of solid inner strength continued throughout the rest of the day and evening. i am overcome by the profundity of the experience..." in the first published scholarly paper [shulgin,a.t. & nichols,d.e.: characterization of three new psychotomimetics. in: stillman,r.c. & willette,r.e. (eds.) the pharmacology of hallucinogens . new york: pergamon, 1978] on mdma use in humans, dr shulgin and dr david nichols describe the effects of mdma on the human psyche as "an easily controlled altered state of consciousness with emotional and sensual overtones." the well-connected stepfather of mdma soon introduced the drug to the wider scientific community. some of dr shulgin's friends, notably the "johnny appleseed of mdma", leo zeff , were professional therapists. they in turn introduced mdma to colleagues as a valuable adjunct to psychotherapy . later, in 1991, dr shulgin and his wife ann published pihkal [phenethylamines i have known and loved]: a chemical love story. pihkal describes the synthesis and systematic testing on human subjects of a range of novel or neglected phenethylamine research drugs. pihkal also offers a uniquely sophisticated methodology for human psychopharmacology and the scientific study of mind as an experimental discipline. by the early 1980s, over a thousand private psychotherapists in the usa were using mdma in their clinical practice. mdma was commonly known as "adam", an allusion to "being returned to the natural state of innocence before guilt, shame and unworthiness arose". mdma was used discreetly; no one wanted a re-run of the 60s. dr shulgin himself reportedly felt mdma came closest to fulfilling his ambition of finding the perfect psychotherapeutic drug. inevitably word leaked out. mdma was profiled by the san francisco chronicle as "the yuppie psychedelic" (10 june 1984). in newsweek , j adler ["high on 'ecstasy", april 15 1985] likened his mdma experience to "a year of therapy in two hours". harpers bazaar described mdma as "the hottest thing in the continuing search for happiness through chemistry". unsurprisingly, mdma use soon spread beyond the couch and clinic to the wider world. mdma's now universal brand-name, "ecstasy", was coined in 1981 by a member of a los angeles distribution network. the unnamed distributor, quoted in bruce eisner 's ecstasy:the mdma story (1989), apparently chose the name "ecstasy" because "it would sell better than calling it 'empathy'. 'empathy' would be more appropriate, but how many people know what it means?" condemned by purists as a cynical marketing ploy, the brand-name "ecstasy" isn't wholly misleading [ecstasy: "an overpowering emotion or exaltation; a state of sudden intense feeling. rapturous delight. the frenzy of poetic inspiration. mental transport or rapture from the contemplation of divine things" ]. many first-time mdma users do indeed become ecstatic. some people report feeling truly well for the first time in their lives. in the early 1980s, american production of mdma beyond the research laboratory was effectively controlled by chemists known as the "boston group". somewhat incongruously, mdma was especially popular in texas, where the southwest distributor for the boston group launched his own commercial operation. mass-production of mdma by the so-called "texas group" began in 1983; supply (and demand) soon mushroomed. ecstasy was distributed openly in bars and nightclubs in dallas and fort worth. it could be purchased via toll-free 800-numbers by credit card. the drug was even marketed via pyramid-style selling-schemes. ecstasy could be bought in little bottles at convenience stores under the label "sassyfras", a tongue-in-cheek allusion to the botanical origins of its precursor. the dea reacted by petitioning to have mdma banned altogether. in 1985 the drug-warriors succeeded in having mdma made schedule one. schedule one is the most restricted of all drug categories i.e. mdma had allegedly "no legitimate medical use or manufa

URL analysis for mdma.net

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https://www.mdma.net/toxicity/mechanisms.html
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https://www.mdma.net/pmma/index.html
https://www.mdma.net/#ecstasy
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uk-legislation.hmso.gov.uk
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Domain Name: MDMA.NET
Registry Domain ID: 2682897_DOMAIN_NET-VRSN
Registrar WHOIS Server: whois.godaddy.com
Registrar URL: http://www.godaddy.com
Updated Date: 2017-09-12T11:41:11Z
Creation Date: 1998-09-12T04:00:00Z
Registry Expiry Date: 2027-09-11T04:00:00Z
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  REGISTRAR GoDaddy.com, LLC

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  ARGS domain =mdma.net

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  TYPE domain

DOMAIN

  NAME mdma.net

  CHANGED 2017-09-12

  CREATED 1998-09-12

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